Problems and strategies in the research of patient-derived gastric cancer xenograft models
10.3969/j.issn.1005-4847.2017.06.010
- VernacularTitle:胃癌人源性异种移植模型制备中的问题与策略
- Author:
quan Bin HU
1
;
Bo CAO
;
hong Chang SHI
Author Information
1. 第四军医大学学员旅
- Keywords:
Gastric cancer;
Patient-derived xenografts( PDX) models;
Targeted drugs;
Genotype characteristics
- From:
Acta Laboratorium Animalis Scientia Sinica
2017;25(6):643-647
- CountryChina
- Language:Chinese
-
Abstract:
In this paper, we summarize the major problems existing in establishing gastric cancer patient-derived xenograft ( PDX) models and its solutions, and introduce its advantages on screening targeted drugs. As many previous re?search emphasized on individual characteristics too much, we argue that we should pay more attention to the generality of what we are studying in order to analyze the genotype of PDX models before taking a targeted therapy.
