Study on the in vitro Release Characteristics of Shengmai Pulse Controlled Release Dropping Pills
- VernacularTitle:生脉脉冲控释滴丸的体外释药特性研究
- Author:
Hao DENG
1
;
Zhijun ZHU
;
Jie DENG
;
Yingli LI
Author Information
1. 河南中医学院药学院 郑州450008
- Keywords:
Pulse controlled release dropping pills;
Central composite design-response surface methodology;
Coating weight gain;
Drug release
- From:
China Pharmacist
2017;20(12):2244-2248
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare Shengmai pulse controlled release dropping pills and investigate the in vitro release. Methods:Shengmai dropping pills were placed in a fluidized bed and coated respectively with an aqueous solution of a swelling layer ( containing croscarmellose sodium) and a controlled release layer ( containing ethylcellulose aqueous dispersion) . The effects of different coating weight gain on the drug release from the swelling layer and the controlled release layer were studied by central composite design-re-sponse surface methodology and in vitro dissolution test. Results:The weight gain of the swelling layer and the controlled release layer was 20% and 10%, respectively, and the expected release time was 4 h. Conclusion:By adjusting the coating weight gain, the drop-ping pills with different release time can be obtained.
