Depressor Substances Test and Histamine Test for the Quality Control of Deproteinized Culf Blood Extrac-tives Injection
- VernacularTitle:降压物质检查法与组胺类物质检查法用于小牛血去蛋白提取物注射液质量控制的研究
- Author:
Tianyan CHEN
1
;
Wen SHAO
;
Haixia LU
Author Information
1. 吉林省药品检验所 长春130033
- Keywords:
Deproteinized culf blood extractives injection;
Depressor substances;
Histamine
- From:
China Pharmacist
2017;20(12):2264-2266
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the applicability of depressor substances test and histamine test for the quality control of depro-teinized culf blood extractives injection. Methods: Depressor substances test and histamine test were carried out on 10 batches of deproteinized culf blood extractives injection samples. Results:Some samples showed positive reactions in the experiments. The correl-ative analysis showed positive correlation existed between the results of depressor substances test and histamine test. However, part of samples causing blood pressure decrease in anesthetized cats showed negative or relatively reduced results in histamine test. Conclu-sion:Deproteinized culf blood extractives injection may be contaminated by depressor substances. Part of these substances may not be histamine analogue, therefore, depressor substances test may be considered in the quality control of the product.
