The therapeutic effect of hydrogen-rich saline on the rheological behavior of leukocytes in mesentery capillary of rats with high-voltage electrical burn
10.3969/j.issn.1673-4130.2017.23.006
- VernacularTitle:富氢盐水对高压电烧伤大鼠肠系膜微血管白细胞流变行为的影响
- Author:
Wei WEI
1
;
Hongbo SHAO
;
Xiaocheng ZHANG
;
Liang XING
;
Meng YANG
;
Jianke FENG
;
Qingfu ZHANG
Author Information
1. 河北医科大学第一医院烧伤整形科
- Keywords:
high-voltage electrical burn;
hydrogen-rich saline;
leukocytes in mesentery capillary;
rheological behavior
- From:
International Journal of Laboratory Medicine
2017;38(23):3231-3233,3236
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effect of hydrogen-rich saline on the rheological behavior of leukocytes in mesentery capillary of rats with high-voltage electrical burn .Methods 180 rats were randomly divided into four groups :burn injury plus normal saline group ,burn injury plus hydrogen-rich saline group ,sham plus normal saline group ,and burn injury plus papaver-ine group .The rats were received saline ,hydrogen-rich saline ,saline ,papaverine at different time points after scald respectively .The changes of rheological behavior of leukocytes in mesentery capillary of rats before and after the injury were investigated .Results The rheological behavior of leukocytes in mesentery capillary of the control group were observed no significant change (P>0 .05) . In experimental group the rolling white blood cell count ,the number of leukocyte adhesion ,the length of contact of leukocyte-endo-thelial cell at each phase after injury were higher than those at 15 min before injury (P<0 .05);leukocyte rolling speed after injury is lower than that before injury (P<0 .05) .In treatment group and positive control group ,the rolling white blood cell count ,the number of leukocyte adhesion ,the length of contact of leukocyte-endothelial cell at each phase after injury were higher than those at 15 min before injury (P<0 .05) ,but compared with the experimental group ,the increase range was lower (P<0 .05) .leukocyte rolling speed after injury is lower than that before injury (P<0 .05) ,and compared with the experimental group ,the reduction was lower (P<0 .05) .Conclusion The hydrogen-rich brine can effectively reduce the changes of rheological behavior of leukocytes in mesentery capillary of rats caused by high-voltage electrical burn ,and have a protective effect on rat mesenteric .
