Correlation analysis between mammographic features and different molecular subtypes of breast cancer
10.3969/j.issn.1002-1671.2017.12.010
- VernacularTitle:乳腺癌X线表现与不同分子亚型的相关性分析
- Author:
Run LIU
1
;
Guanglin LI
;
Yan DONG
;
Junle YANG
;
Xiaoping WU
;
Mingyue MA
;
Min XU
;
Yi LI
Author Information
1. 西安交通大学附属西安市中心医院放射科
- Keywords:
breast cancer;
molecular subtypes;
mammography
- From:
Journal of Practical Radiology
2017;33(12):1851-1854,1862
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between mammographic findings and different molecular subtypes of breast cancer.Methods Totally 84 patients with breast cancer proved pathologically who underwent digital mammography examination before operation were enrolled.All cases were examined by immunohistochemical staining,the expression levels of estrogen receptor(ER),progesterone receptor (PR)and human epidermal growth factor receptor-2(HER-2)in tumor cells were analyzed.They were classified into four molecular subtypes:Luminal A,Luminal B,HER-2 + and Basal-like tumors according to their expression levels.The correlation between mammographic findings and different molecular subtypes of breast cancer were analyzed.Results Among the 84 cases of breast cancer,there were significant differences between mass shadow and mass shape in the four subtypes of tumors(P<0.05).Luminal A,Luminal B breast cancer showed more irregular edge of the tumor;HER-2 + breast cancer with more malignant calcifications,of which simple calcifications of breast cancer were more;Basal-like breast cancer with regular shape,clear border shadow,rarely accompanied by malignant calcifications.Conclusion Mammographic features of breast cancer can predict its molecular subtypes to some extent,which can provide objective basis for the selection of clinical preoperative treatment protocols.
