Influencing Factors in Fluidized Bed Granulation Process of Metformin Hydrochloride
- VernacularTitle:盐酸二甲双胍流化床制粒工艺的影响因素研究
- Author:
Xiaofei ZHANG
1
;
Qiuting GUO
Author Information
1. 陕西中医药大学药学院 陕西省中药制药重点学科 陕西咸阳712000
- Keywords:
Fluidized bed granulation;
Metformin hydrochloride;
Physical properties of granule
- From:
China Pharmacist
2017;20(12):2145-2149
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effects of process parameters of fluidized bed granulation on the physical properties of metform-in hydrochloride granule. Methods:The physical properties of metformin hydrochloride were used as the evaluation indices. Single fac-tor experiment was conducted to investigate the influences of equipment factors ( including the nozzle height and the nozzle orifice) and the process parameters ( including binder dosage, inlet air temperature, inlet air flow rate, spray rate and atomization pressure) on the physical prperties. Results: The influences of equipment factors on the physical properties of the granule were not significant. The binder dosage, inlet air temperature, inlet air flow rate, spray rate and atomization pressure showed significant influences on the physi-cal properties of metformin hydrochloride granule. Conclusion:The parameters of fluidized bed granulation process ( binder dosage, in-let air temperature, inlet air flow rate, spray rate and atomization pressure) have significant effects on the physical properties of met-formin hydrochloride granule, which should be controlled according to the requirements of granule properties.
