Relationship between the expression of CEA,CA125,CA72-4 and wnt/ β signaling pathway in patients with gastric cancer and the prognosis
10.3760/cma.j.issn.1008-6315.2017.11.003
- VernacularTitle:胃癌患者血清中CEA、CA125、CA72-4和wnt/β-catenin信号通路表达与患者预后的关系
- Author:
Zhenyu LEI
1
Author Information
1. 200237,上海市徐汇区大华医院普外科
- Keywords:
Gastric Cancer;
CEA;
CA-125;
CA72-4;
wnt/β-catenin;
Prognosis
- From:Clinical Medicine of China
2017;33(11):969-972
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between CEA,CA125,CA72-4 and wnt/ β signaling pathway in the serum of patients with gastric cancer and prognosis.Methods Eighty-five cases with gastric cance treated in Dahua Hospital of Shanghai Xuhui District from June 2015 to June 2016 year served as the research objects,the expression of CEA,CA125,CA72-4 and wnt/ β-catenin signaling pathway were detected and their relationship with the chemotherapy effect and clinical prognosis of the patients was examined.Results There was significant differences in CEA,CA-125,CA724,wnt,Tcf-4,β-catenin level among the progression of the disease(PD),stable(SD),partial remission(PR),complete remission(CR)patients(F=28.60,35.50, 32.40,33.80,39.50,36.50,P<0.05).In addition,the levels in PD patients were significantly higher than those in SD,PR,CR patients.In patients with death,metastasis,recurrence,and stabilization,there was significant differences in CEA,CA-125,CA724,wnt,Tcf-4 and β-catenin level(F=28.60,35.50,32.40,33.80,39.50, 36.50,P<0.05),Patients with death were significantly higher than those with metastasis,recurrence and stabilizatio.Wnt(P=0.030),Tcf-4(P=0.03),β-catenin(P=0.02)and CA72-4 level(P= 0.04)were independent risk factors for death in patients with gastric cancer.Conclusion The expression of CEA,CA125, CA72-4 and wnt/β-catenin signaling pathway in patients with gastric cancer is closely related to the prognosis.
