Therapeutic effect of trimetazidine on patients with angina pectoris after PCI and its influence on endo-thelial function and exercise tolerance
10.3969/j.issn.1008-0074.2017.06.14
- VernacularTitle:曲美他嗪治疗PCI术后心绞痛患者的疗效及其对内皮功能和运动耐量的影响
- Author:
Zhong QIN
1
;
Hai ZHU
;
sen Shu LIAO
;
Jun ZHOU
Author Information
1. 北海市人民医院心血管内科
- Keywords:
Angina pectoris;
Angioplasty;
balloon;
coronary;
Trimetazidine
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2017;26(6):635-639
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study therapeutic effect of trimetazidine on patients with angina pectoris after percutaneous coronary intervention(PCI)and its influence on endothelial function and exercise tolerance.Methods:A total of 108 patients with angina pectoris after primary PCI in our hospital were selected,randomly and equally divided into routine treatment group and trimetazidine group(received trimetazidine therapy since second month after PCI based on routine treatment).Therapeutic effect after treatment,endothelial function and exercise tolerance before and after treatment were compared between two groups.Results:Total effective rate of trimetazidine group was signifi-cantly higher than that of routine treatment group(98.15% vs.83.33%,P=0.008).Compared with before treat-ment,there were significant improvements in angina pectoris onset condition and cardiac function,significant rise in endothelial function and exercise tolerance in two groups after treatment,P<0.05 or <0.01;compared with rou-tine treatment group after treatment,there were significant reductions in mean onset times[(2.91 ± 1.25)times/month vs.(1.72 ± 1.04)times/month]and duration[(2.06 ± 1.08)h vs.(1.24 ± 0.97)h]of angina pectoris,ni-troglycerin dose[(1.21 ± 0.12)g vs.(0.84 ± 0.11)g],depression magnitude[(0.16 ± 0.05)mV vs.(0.13 ± 0.05)mV]and time[(18.64 ± 6.41)min vs.(6.74 ± 4.82)min]of ST segment,T wave inversion magnitude [(0.18 ± 0.04)mV vs.(0.09 ± 0.05)mV]and endothelin-1 level[(50.44 ± 7.43)ng/L vs.(41.08 ± 6.02)ng/L],and significant rise in left ventricular ejection fraction[(54.18 ± 8.25)% vs.(57.82 ± 7.73)%],6min walking distance[(512.74 ± 86.66)m vs.(551.24 ± 84.69)m],fore brachial artery endothelium dependent diastolic-sys-tolic function[(10.08 ± 3.1)% vs.(11.79 ± 3.24)%]and nitric oxide level[(83.14 ± 5.15)μmol/L vs.(116.22 ± 6.54)μmol/L]in trimetazidine group,P<0.05 or <0.01. Conclusion:Trimetazidine possesses good treatment effect on angina pectoris after PCI,and it can effectively improve endothelial function and exercise tolerance,which is worth extending.
