Principles of necropsy and gross pathology examination for toxicologic pathology assessment
10.7501/j.issn.1674-6376.2017.10.001
- VernacularTitle:毒性病理学评价中动物剖检及大体病理学检查原则
- Author:
tao Gui HUO
1
;
jun Jian LV
;
Zhe QU
;
Zhi LIN
;
wei Yan YANG
;
Di ZHANG
;
Yan HUO
;
chao Xing GENG
;
Xue WANG
;
Bo LI
Author Information
1. 中国食品药品检定研究院国家药物安全评价监测中心药物非临床安全评价研究北京市重点实验室
- Keywords:
toxicologic pathology;
necropsy;
gross pathology;
safety evaluation;
standard operating procedures (SOPs)
- From:
Drug Evaluation Research
2017;40(10):1365-1371
- CountryChina
- Language:Chinese
-
Abstract:
Toxicologic pathology plays an important role in the safety evaluation of drugs.The results of toxicologic pathology can answer the basic problems of pathological lesions such as location,severity grading,nature and prognosis,etc.Necropsy and gross pathology examination are important aspects of toxicologic pathology assessment.Procedures typically include preparation for the necropsy,euthanasia procedures,identification and recording all gross lesions,collection of tissues listed in the study protocol,determination of organ weight,as well as tissue fixation so as to be ready for the subsequent tissue processing and histopathology examination.All the procedures must be done in a consistent manner and in accordance with standard operating procedures (SOPs).The present paper briefly introduced the principles of necropsy and gross pathology examination for toxicologic pathology in order to standardize the procedures and to lay foundation for the improvement of the histopathology examination in the field of preclinical safety evaluation of drugs of China.
