Association of tumor necrosis factor-α gene promoter polymorphisms with generalized pustular psoriasis
10.3760/cma.j.issn.0412-4030.2017.12.005
- VernacularTitle:肿瘤坏死因子α基因启动子多态性与泛发性脓疱性银屑病相关性研究
- Author:
Fuquan LONG
1
;
Yeqiang LIU
;
Yihong QIAN
;
Bingxin MENG
;
Lishi ZHAO
;
Qianqiu WANG
Author Information
1. 200043,上海市皮肤病医院性病科
- Keywords:
Psoriasis;
Tumor Necrosis Factor-alpha;
Polymorphism,single nucleotide;
Transcription Initiation Site;
Generalized pustular psoriasis
- From:
Chinese Journal of Dermatology
2017;50(12):879-882
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of tumor necrosis factor-ot (TNF-α) gene promoter polymorphisms with generalized pustular psoriasis.Methods Totally,91 patients of Han nationality with generalized pustular psoriasis (generalized pustular psoriasis group) and 102 health checkup examinees (healthy control group) were enrolled into this study.PCR and direct sequencing were performed to analyze the-238,-308 and-857 polymorphic sites of the TNF-α promoter.Results The frequency of the A allele at TNF-α-238 site was significantly higher in the generalized pustular psoriasis group than in the healthy control group (P =0.003,OR =4.819,95％ CI:1.581-14.694),so was the frequency of GA/AA genotype (P =0.006,OR =4.455,95％ CI:1.410-14.077).However,no significant differences were observed in the frequencies of G/A alleles (P =0.794) and GG/GA/AA genotypes (P =0.786) at TNF-o-308 site,or in the frequencies of C/T alleles (P =0.474) and CC/CT/TT genotypes (P =0.453) at TNF-α-857 site,between the generalized pustular psoriasis group and healthy control group.Conclusion TNF-α-238G ＞ A polymorphisms may be associated with the occur-rence of generalized pustular psoriasis.
