Diagnosis and risk stratification of multiple myeloma
10.3760/cma.j.issn.1009-9921.2017.12.002
- VernacularTitle:多发性骨髓瘤的诊断及危险分层
- Author:
Xuehan MAO
1
;
Lugui QIU
;
Gang AN
Author Information
1. 中国医学科学院 北京协和医学院 血液学研究所 血液病医院淋巴瘤诊疗中心 实验血液学国家重点实验室
- Keywords:
Multiple myeloma;
Diagnostic criteria;
Risk stratification
- From:
Journal of Leukemia & Lymphoma
2017;26(12):708-711,715
- CountryChina
- Language:Chinese
-
Abstract:
Multiple myeloma (MM) is a clonal malignancy characterized by the infiltration of clonal plasma cells in the bone marrow and monoclonal M protein in peripheral blood and urine. MM can be divided into smoldering multiple myeloma (SMM) with no obvious symptoms and active MM which can be diagnosed according to the end-organ damaging caused by clonal proliferation of plasma cells. When it happens, the patients need to receive systematic treatment. SMM patients without high risk factors merely need the routine observation and following-up. Therefore, right diagnosis and differential diagnosis are related with the indication and timing of treatment. Besides, MM is a very heterogeneous disease with overall survival from a few months to more than ten years. Accurate risk stratification in the initial diagnosis plays a key role in realizing individual treatment and improving prognosis.
