The clinical and laboratory features of IgG-2κ light chain multiple myeloma: analysis of three cases
10.3760/cma.j.issn.1009-9921.2017.12.011
- VernacularTitle:IgG-2κ轻链型多发性骨髓瘤三例临床和实验室特征
- Author:
Yajun JIANG
1
;
Wanchuan ZHUANG
;
Xiumei LI
;
Guihua ZHU
;
Xiangyun HU
;
Yao HE
;
Xingxing CHAI
;
Xiaoyun YANG
Author Information
1. 222002,蚌埠医学院附属连云港医院血液科
- Keywords:
Multiple myeloma;
Immunoglobulin G;
Immunoglobulin light chains;
Immunofixation electrophoresis
- From:
Journal of Leukemia & Lymphoma
2017;26(12):748-751
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical and laboratory features of IgG-2κ light chain multiple myeloma. Methods The clinical data and laboratory results of 2 multiple myeloma (MM) patients with IgG-2κ light chain were analyzed and the related literatures were reviewed. Results Two male and 1 female patients were 50-82 years old and mainly suffered with backache, infection, anemia and renal dysfunction. Multiple osteolytic bone destruction was detected in X-ray as well as magnetic resonance imaging (MRI). The level of serum IgG was normal, slight or obviously increased, but the levels of IgA and IgM were decreased. The levels of κ light chain in serum and urine were both increased significantly, and Bence-Jones protein was positive. Double M protein peaks of serum in γ area were detected by protein electrophoresis in 2 patients. A single band of IgG and double bands of light chain κ were revealed by immunofixation electrophoresis. Bone marrow smear showed that abnormal plasma cells were increased obviously. One patient gave up chemotherapy because of lung infection, acute left heart failure and acute renal failure, the others 2 patients achieved partial remission and stable disease by receiving DVD and VAD chemotherapy. Conclusions IgG-2κ light chain MM lacks typical clinical presentation, but some laboratory characteristics may be different from those of IgG-κ light chain. Further researches are needed to confirm whether or not it belongs to biclonal MM.
