Evaluation of combination therapy with α and M receptors antagonist for the treatment of double J stents related lower urinary tract symptoms
10.3760/cma.j.issn.1008-6315.2017.11.014
- VernacularTitle:α受体及M受体阻滞剂联合应用治疗留置双J管致下尿路症状的效果分析
- Author:
Tao JIANG
1
;
Yonghui WANG
;
Jun GAO
Author Information
1. 113008,抚顺矿务局总医院药剂科
- Keywords:
Double J Stent;
Lower Urinary Tract Symptom;
Solifenacin;
Tamsulosin
- From:
Clinical Medicine of China
2017;33(11):1018-1021
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of combination therapy with α and M receptors antagonist for the treatment of double J stents related lower urinary tract symptoms.Methods From January 2013 to December 2016,one hundred and twenty patients were accepted the doubte J stents indwelling after the ureteral lithotripsy,laparoseopie ureterlithotomy and pyeloureteroplasty.They were divided into four groups randomly,including control group(30 cases,no drugs were taken),tamsulosin group(30 cases,0.2 mg tamsulosin was taken qd),solifenacin group(30 cases,5 mg solifenacin was taken qd),combination group(30 cases,0.2 mg tamsulosin and 5 mg solifenacin were taken qd).The IPSS scores,QOL scores and visual analogue pain scale(VAPS)scores were assessed pre-operation,1 week after operation,and 4 weeks after operation, respectively.Results The total IPSS scores in the combination group 4 weeks after operation was(8.21±2.36) points,compared with the control group((13.68 ± 3.65)points),the tamsulosin group((12.59 ± 3.76) points),the solifenacin group((12.39 ±4.58)points),the difference was statistically significantly lower(F=7.905,P<0.05).And 4 weeks after operation,the QOL scores in the combination group((1.52±0.99)points) was significantly lower than that in the control group((2.86±1.14)points),the tamsulosin group((2.69± 1.21)points)and the solifenacin group((2.74 ± 1.40)points)(F=13.725,P<0.05).While the VAPS scores didn′t show significant differences among those groups(P>0.05).Conclusion α and M receptors antagonist combination therapy can significantly improve lower urinary tract symptom due to indwelling double J stents.
