Evaluation of liver reserve function with Gd-EOB-DTPA enhanced MRI in patients with hepatitis B cirrhosis
10.3969/j.issn.1002-1671.2017.12.015
- VernacularTitle:Gd-EOB-DTPA增强MRI评估乙肝肝硬化患者肝脏储备功能
- Author:
Jiyun ZHANG
1
;
Jian LU
;
Xueqin ZHANG
;
Tao ZHANG
;
Jifeng JIANG
;
Ding DING
;
Sheng DU
Author Information
1. 南通大学附属南通第三医院影像科
- Keywords:
liver reserve function;
contrast media;
magnetic resonance imaging
- From:
Journal of Practical Radiology
2017;33(12):1870-1873
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the ability of Gd-EOB-DTPA enhanced MRI in the evaluation of liver reserve function in patients with hepatitis B cirrhosis.Methods Patients with hepatitis B cirrhosis and controls with normal liver function and free of chronic liver disease were collected prospectively.Signal intensity(SI)of each hepatic segments(S1-S8)were measured of all cases before injection and after bolus administration of Gd-EOB-DTPA,and the whole liver signal intensity was assessed as the average signal intensity.The whole liver relative enhancement degree(relative enhancement RE)was calculated.The one way A NOVA was used to compare SI and RE among four groups at different time and the Friedman test was used to compare SI and RE within each group at different time.The Spearman rank correlation analysis was used to do correlation analysis.ROC curve was used to analyze the efficacy of Gd-EOB-DTPA enhanced MRI in the diagnosis of liver dysfunction and was used to compare the diagnostic performance of SI and RE in discriminating normal liver function group-Child A from Child B-C.Results Patients enrolled with normal liver function,Child-Pugh A,B and C was 21, 40,48 and 11.SI and RE between different groups were statistically significant at each time(P<0.05);and was statistically significant at different time within the same group.Correlation analysis of SI and RE with liver function classification at different time points showed:in addition to SI20 s(r= -0.190,P= 0.038),RE20 s(r=0.081,P=0.382),SI and RE at each time point were highly negatively related with liver function classification(P<0.01).SI10 minand RE10 minwere higher significantly negatively related with liver function classification.T he area under the ROC curve was 0.839,0.707,0.779 and 0.547,respectively.Conclusion Gd-EOB-DTPA enhanced MRI can assess liver reserve function in patients with hepatitis B cirrhosis,SI and RE can reflect the degree of liver function reserve in a certain extent.It has some value in predicting the normal or mild injury of liver function with moderate or severe injury of liver function.
