Advances in research on the role of Siglec-1 in diseases
10.3969.j.issn.1671-7856.2017.12.019
- VernacularTitle:唾液酸黏附素Siglec-1在疾病中作用的研究进展
- Author:
lei Ke LI
1
;
Xiang LI
;
Zhe CONG
;
Jing XUE
Author Information
1. 北京协和医学院比较医学中心
- Keywords:
Siglec-1;
Inflammation;
Immunoregulation;
HIV
- From:
Chinese Journal of Comparative Medicine
2017;27(12):109-114
- CountryChina
- Language:Chinese
-
Abstract:
Sialoadhesin ( Siglec-1 or CD169 ) is a sialic acid-binding Ig-like lectin expressed selectively on macrophage subsets. In inflammatory response, Siglec-1 can modulate the secretion of MIP-1 alpha / beta, MCP-1, MIP-2 and other cytokines, and promote the occurrence of inflammatory reaction. During viral infection, Siglec-1 can promote the infection and phagocytosis of virus by mediating the binding of pathogens and macrophages. In the regulation of immunity, Siglec-1 can regulate innate immunity and adaptive immunity, by inhibiting the excessive expression of IFN-α and the activation of DC cells. This review mainly focuses on the new advances of research on Siglec-1 in pathogen infections, inflammation and immunoregulation.