Research progress of bronchoalveolar lavage in rats and mice
10.3969.j.issn.1671-7856.2017.12.020
- VernacularTitle:大、小鼠支气管肺泡灌洗术的研究进展
- Author:
Long LONG
1
;
li Xian ZHAO
;
Hong TAN
;
hua Ai ZHANG
;
bo Hong YANG
;
lin Jin HE
Author Information
1. 贵州医科大学公共卫生学院
- Keywords:
Bronchoalveolar Lavage;
Animal experiment;
Respiratory system
- From:
Chinese Journal of Comparative Medicine
2017;27(12):115-119
- CountryChina
- Language:Chinese
-
Abstract:
Bronchoalveolar lavage is an important animal experimental technique in the study of respiratory system and its pathological changes. It can acquire a variety of biochemical factors, inflammatory mediators and immune cells from the respiratory tract and lungs, and provides an important evaluation index and reference for animal experiment. Bronchoalveolar lavage is an effective and reliable method for the diagnosis of respiratory diseases. It has been gradually standardized and widely used in clinical practice at present, however, there is no set of standard for bronchoalveolar lavage in rats and mice. The results of bronchoalveolar lavage fluid are affected by many factors, such as the lavage fluid, suction pressure, the amount of lavage and recovery, and the retention time of lavage fluid in the lungs. Successful and efficient acquisition of lavage specimens is the key to the study and evaluation of respiratory diseases. This paper summarizes the current lavage methods commonly used by domestic and foreign researchers, and provides a reference for further research in the this field.
