Problems in serum antibody detection of smear-and culture-negative pulmonary tuberculosis

VernacularTitle:血清学抗体检测菌阴肺结核存在的问题讨论
Author: Lei YANG ¹ ; Jun CAO ; Jinbiao LU ; Guozhi WANG ; Miao XU
Author Information

1. 102629,中国食品药品检定研究院结核病疫苗室
Keywords: Tuberculosis/diagnosis; Smear-and culture-negative pulmonary tuberculosis; Serum antibody detection
From: Chinese Journal of Microbiology and Immunology 2017;37(10):785-789
CountryChina
Language:Chinese
Abstract: More than 60% of active tuberculosis(TB) patients are smear- and culture-negative, constituting a prime group in the prevention and control of TB in China. In the existing laboratory testing technologies, immunological diagnosis is more advantageous than etiological diagnosis in the detection of smear-and culture-negative TB. Serum antibody detection reagents are cheap,easy to operate and time-sav-ing,and have been widely used in China. However,these agents are not stable in sensitivity and specificity, and because of that their accuracy in the diagnosis of smear-and culture-negative TB is doubtful. In this re-view,we summarize some problems in the use of serum antibody detection among smear- and culture-nega-tive pulmonary TB patients and discuss possible methods to solve these problems expecting to provide some ideas for promoting its development,application and policy formulation.