Recent progress in Staphylococcus aureus α-hemolysin
10.3760/cma.j.issn.0254-5101.2017.10.013
- VernacularTitle:金黄色葡萄球菌α-溶血素的研究进展
- Author:
Feng ZHENG
1
;
Tingting ZHOU
;
Qiannan SUN
;
Jin ZHU
Author Information
1. 210002,南京军区疾病预防控制中心
- Keywords:
Staphylococcus aureus;
α-hemolysin;
Bacterial toxin
- From:
Chinese Journal of Microbiology and Immunology
2017;37(10):795-801
- CountryChina
- Language:Chinese
-
Abstract:
Staphylococcus aureus(S.aureus) secretes a variety of pathogenic toxins and one of the most prominent toxins is α-hemolysin,which is considered as the main virulence factor in skin necrosis and severe infections caused by S.aureus infection. α-hemolysin is so named because of its ability to dissolve red blood cells. However,it has a wide range of effects on various cells and may cause different pathogenic re-sponses in different host cells. This review summarizes recent studies on the structure of α-hemolysin and its interaction with different cells in order to better understand the role of α-hemolysin in the process of S.aureus infection,which may provide a reference for developing new approaches to the prophylaxis and treatment of S.aureus infection.
