Association of the gene polymorphism of cytotoxic T lymphocyte-associated antigen-4 with Graves ophthalmopathy in Qinghai Tibetans
10.3760/cma.j.issn.1000-6699.2017.11.010
- VernacularTitle:中国青海藏族Graves眼病与CTLA-4基因多态性的相关性
- Author:
Shuqiong WANG
1
;
Yongli YAO
Author Information
1. 青海省人民医院内分泌Ⅱ病区
- Keywords:
Graves'disease;
Polymorphism;
restriction fragment length
- From:
Chinese Journal of Endocrinology and Metabolism
2017;33(11):962-964
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the association of the gene polymorphism of cytotoxic T lymphocyte-associated antigen-4(CTLA-4)with Graves'ophthalmopathy(GO)in Qinghai Tibetans. 130 case of Graves'disease(GD)were selected from June 2013 to November 2016 in The People's Hospital of Qinghai Province. These patients were assigned into 2 groups,GO(n=71)and GD without GO(n=59). The genotypes and alleles of CTLA-4 gene were detected by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP). Distribution of CTLA-4 exon 1 (+49A/G)genotype frequencies(AA,AG,and GG)was different between 2 groups.
