Progress in research of KISS1/KISS1R system and reproductive function
10.3760/cma.j.issn.1000-6699.2017.11.019
- VernacularTitle:Kiss1/Kiss1受体系统与生殖功能的研究进展
- Author:
Liangchun CAI
1
;
Junping WEN
;
Gang CHEN
Author Information
1. 福建省立医院内分泌科
- Keywords:
Kiss1;
Kiss1 receptors;
Kisspeptin;
Reproduction;
Puberty
- From:
Chinese Journal of Endocrinology and Metabolism
2017;33(11):1001-1006
- CountryChina
- Language:Chinese
-
Abstract:
Kiss1 gene encodes Kisspeptins,an intercellular signal peptide whose corresponding receptor is Kiss1R. The initial study found that the Kiss1/Kiss1R system has the effect on inhibiting tumor metastasis. More and more evidence suggests that it can act on the hypothalamic-pituitary-gonadal(HPG) axis and is the key to puberty initiation and progression. It plays an important role in the neuroendocrine regulation of reproduction. In this paper, we reviewed the studies on Kiss1/Kiss1R system,its intracellular signal transduction pathway,role on HPG axis,and clinical application.
