Protective effects of Toddalia asiatica extract on oxidative damages in mice with myocardial ischemia and hyperlipidemia
10.3969.j.issn.1671-7856.2017.12.009
- VernacularTitle:飞龙掌血提取物对高脂血症心肌缺血小鼠氧化损伤的影响
- Author:
Ming LIU
1
;
Ying DENG
;
Yang LIU
;
Yun CHEN
Author Information
1. 贵阳中医学院基础医学院
- Keywords:
Toddalia asiatica;
Hyperlipidemia;
Myocardial ischemia;
Oxidative damages
- From:
Chinese Journal of Comparative Medicine
2017;27(12):51-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of Toddalia asiatica extract( TAE) on oxidative damages in mice with myocardial ischemia and hyperlipidemia. Methods Fifty SPF male KM mice were randomly divided into 5 groups:control group,model group,simvastatin group (5 mg/kg),high-dose TAE group (400 mg/kg) and low-dose TAE group (100 mg/kg) . Hyperlipidemia was induced by feeding milk for 4 weeks. At the same time,the corresponding drug was given by oral administration with 20 mL/kg for 28 d. At the end of four-week treatment, isoprenaline hydrochloride ( Iso ) was subcutaneously injected every 24 hours for three times. The body weight, electrocardiogram, heart and liver indexes, myocardial water content, and the serum levels of TC, TG, HDL, LDL, SOD, MDA and GPx were measured. Results TAE significantly improved the electrocardiogram changes induced by Iso and milk in the mice, weight lose, inhibited the heart and liver indexes, reduced the myocardial water content, decreased the levels of TC, TG, LDL and MDA, and increased the contents of HDL, SOD and GPx. Conclusions TAE may play an important role in cardiovascular protection by regulating oxygen free radical metabolism and improving oxidative damages.
