Promoting effect of intermedin and adrenomedullin on cerebral microcirculation in rat models of cerebral ischemia
10.3969.j.issn.1671-7856.2017.12.012
- VernacularTitle:中介素与肾上腺髓质素对局灶性脑缺血大鼠脑微循环的影响
- Author:
Xin GUO
1
;
Jing WANG
;
Meng WANG
;
ying Yue LU
;
na Na JIA
;
gang Zhen LIU
;
rui Jing TIAN
;
Jie YUAN
Author Information
1. 华北理工大学附属医院神经内科
- Keywords:
Intermedin;
Adrenomedullin;
Cerebral Ischemia;
Microcirculation;
Rats
- From:
Chinese Journal of Comparative Medicine
2017;27(12):66-72
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of intermedin ( IMD ) and adrenomedullin ( ADM ) on cerebral microcirculation in rats with cerebral ischemia. Methods Rat cerebral ischemia ( CI) model was established by middle cerebral artery occlusion. 40 SPF male adult Sprague-Dawley ( SD) rats were randomly divided into three groups:CI+NS ( normal saline) group, CI+ADM group and CI+IMD group, which were used to observe the changes of brain surface microcirculatory perfusion with a laser Doppler flowmeter. Results The differences of brain surface microcirculatory perfusion were statistically significant among the CI+NS group, CI+ADM group and CI+IMD group ( F=53. 426, P<0. 05 ) . Multiple comparison showed that the brain surface microcirculatory perfusion in the CI+IMD group was higher than that of the CI+NS group and CI+ADM group. Conclusions Intermedin can improve the cerebral microcirculation in rats with cerebral ischemia, and its therapeutic effect is better than adrenomedullin.
