Application of chromosomal microarray technique in genetic analysis of patients with embryo development arrest
10.3969/j.issn.1006-5725.2017.20.033
- VernacularTitle:微阵列检测技术在早期胚胎停育中的应用
- Author:
Liping LIU
1
;
Jieqiong ZHOU
;
Ruilong GONG
;
Li HOU
;
Xiaojie SONG
;
Yuxia LI
Author Information
1. 华中科技大学同济医学院附属武汉儿童医院(武汉市妇幼保健院)妇产科
- Keywords:
embryo development arrest;
microarray analysis;
copy number variants
- From:
The Journal of Practical Medicine
2017;33(21):3631-3634
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of chromosomal microarray technique in genetic analysis of patients with embryo development arrest. Methods A total number of 273 patients with embryo development arrest were recruited for the chromosomal microarray testing.Results 41.4% of the 273 patients were chromosomal abnormalities. Among which 61(22.34%)were numerical chromosomal abnormalities,43 were structural anoma-lies,including which 15.75% were terminal deletion or duplication and microdeletion or microduplication. And 9 (3.3%)were mosaicisms.Conclusions Chromosomal microarray technique is highly accurate and specific,which can offer more genetic information than conventional karyotyping. And chromosomal microarray technique can also facilitate estimation of recurrence risk of future pregnancies for patients with embryo development arrest.
