The expression and significance of macrophagecolony stimulating factor in patients with cervical lntraepi-theliai neoplasia or cervical cancer
10.3969/j.issn.1006-5725.2017.21.034
- VernacularTitle:巨噬细胞集落刺激因子在宫颈癌及宫颈上皮内瘤变患者血清中的表达及意义
- Author:
Kaixian DENG
1
;
Yuhua ZHENG
;
Xiaochun LIU
;
Hong WANG
;
in Luq HU
;
Yonglian CHEN
;
Yuling WANG
;
Xiaobin HUANG
;
Linxi LI
Author Information
1. 南方医科大学附属佛山市妇幼保健院妇科
- Keywords:
cervical cancer;
cervical intraepithelial neoplasia;
squamous cell carcinoma antigen;
Macrophagecolony Stimulating factor
- From:
The Journal of Practical Medicine
2017;33(21):3635-3638
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the levels of plasma M-CSF in cervical cancer patients and cervical intraepitheliai neoplasia(CIN)patients,and to discuss the diagnostic utility of M-CSF in the development of cervi-cal cancer. Methods Forty-nine cases of cervical cancer,60 cases of CIN and 40 healthy controls were selected from June 2014 to June 2016. Plasma levels of M-CSF and SCC-Ag were determined by using ELISA and MEIA, respectively. Results Significantly different concentrations of M-CSF and SCC-Ag were observed in patients with cervical cancer compared to the healthy controls and CIN patients(P<0.01,respectively). Significant difference in plasma M-CSF level between the healthy controls and benign lesion patients were also found(P<0.05).However, no significant difference in SCC-Ag was found between the healthy controls and benign lesion patients. SCC-Ag combined M-CSF could obviously increase the detection rate of cervical cancer,without increasing the false posi-tive rate. The level of M-CSF in patients with cervical cancer and high grade of CIN reduced to the normal level, with significant difference before and after surgery(P<0.05).Meanwhile,the level of SCCAg in CIN patients was significantly reduced before and after surgery(P<0.05).Conclusions This study suggests the potential utility of M-CSF as a good candidate for a serum marker of cervical cancer,as well as benign lesions of this organ(CIN), and M-CSF may also be use to predict the outcome of CIN.
