Research Progress of MALDI-TOF-IMS in Biomedicine and Its Application Prospect in Forensic Sciences
10.3969/j.issn.1004-5619.2017.05.016
- VernacularTitle:MALDI-TOF-IMS在生物医学中的研究进展及法医学应用展望
- Author:
heng Guan REN
1
;
hua Rong WENG
;
Yan SHI
;
Ping HUANG
;
dong Zheng LI
;
Yu SHAO
;
fei Kai DENG
;
guo Ning LIU
;
jiu Yi CHEN
Author Information
1. 司法鉴定科学研究院上海市法医学重点实验室上海市司法鉴定专业技术服务平台
- Keywords:
forensic pathology;
imaging mass spectrometry;
review;
matrix-assisted laser desorption;
ionization
- From:
Journal of Forensic Medicine
2017;33(5):522-525
- CountryChina
- Language:Chinese
-
Abstract:
Matrix-assisted laser desorption/ionization time-of-flight imaging mass spectrometry (MALDI-TOF-IMS) can analysis unknown compounds in sections and obtain molecule imaging by scanning biological tissue sections,which has become a powerful tool for the research of biomarker,lipid distribution and drug metabolism,etc.This article reviews the application of this technique in protein identification,clinical application,drug discovery,lipid research and brain injury.
