Role and significance of Febuxostat on NALP3 inflammasome in chronic gouty arthritis
10.3969/j.issn.1006-5725.2017.21.026
- VernacularTitle:非布司他对慢性痛风性关节炎中NALP3炎性体的作用及意义
- Author:
Xiaoyan CAI
1
;
Guangfu DONG
Author Information
1. 510170,广州医科大学附属第三医院荔湾医院风湿科
- Keywords:
chronic gouty arthritis;
febuxostat;
NALP3 inflammasome
- From:
The Journal of Practical Medicine
2017;33(21):3602-3605
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Febuxostat on NALP3 inflammasome in chronic gouty arthri-tis. Methods A total of 89 patients with chronic gouty arthritis and 50 healthy cases were enrolled in this study and 89 patients were divided into Benzbromarone group,Allopurinol group,Febuxostat group and placebo group. The expression of NALP3 inflammasome mRNA and the protein were detected by RT-PCR and Western blot. Re-sults The levels of Uric Acid,NALP3,ASC and caspase-1 mRNA in chronic gouty arthritis patients were higher than those in healthy cases before treatment(#P = 0.000);the level of NALP3 in benzbromarone and allopurinol group had no change after treatment(*P<0.05).The levels of NALP3 mRNA and caspase-1 mRNA in Febuxostat group were lower but the level of ASC mRNA was higher than those in other groups after treatment(*P < 0.05). Conclusions NALP3 inflammatory may be associated with chronic gouty arthritis. Febuxostat can effectively re-duce the level of Uric Acid,and affect the function of NALP3 inflammasome.
