Correlation Study Between CDKN2B-AS1 Gene Polymorphism and Female Premature Coronary Artery Disease Occurrence
10.3969/j.issn.1000-3614.2017.12.003
- VernacularTitle:CDKN2B-AS1基因多态性与女性早发冠心病的相关性研究
- Author:
Lin QIAO
1
;
yan Xing WEN
;
fei Ke DOU
;
Dong YIN
;
hua Wei SONG
;
na Chan ZHANG
;
Kai SUN
;
tai Ru HUI
;
jian Hong WANG
Author Information
1. 北京协和医学院 中国医学科学院 国家心血管病中心 阜外医院 心内科
- Keywords:
Coronary artery disease;
Gene;
Female
- From:
Chinese Circulation Journal
2017;32(12):1154-1157
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between single nucleotide polymorphism (SNP) rs4977574 in CDKN2B-AS1 gene and female premature coronary artery disease (pCAD) occurrence. Methods: Our research included 2 groups: pCAD group, n=226 consecutive patients≤65 years of age and Control group, n=79 subjects with matched age,without CAD. The genotype of CDKN2B-AS1 SNP rs4977574 was detected by SNaPshot. Blood levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), uric acid (UA), fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1c) were examined; relationships between rs4977574 polymorphism and the above parameters were assessed. Results: Compared to Control group, pCAD group had increased blood levels of TG, UA, FPG and HbA1c, P<0.05. With adjusted age, body mass index (BMI), relevant disease history and risk factors, elevated HbA1c (HbA1c>6.2%) obviously increased the risk of female pCAD occurrence (OR=3.35, 95%CI 1.41-8.00, P=0.006). The genotype and allele frequency of rs4977574 were different between pCAD group and Control group, P<0.05. Compared to Control group, pCAD group had the higher frequency of G allele(OR=1.24, 95%CI 1.05-1.48, P=0.019); further analysis found that rs4977574 polymorphism was related to high HbA1c. Compared to AA genotype, GG+GA genotype had the increased incidence of high HbA1c(OR=2.08, 95%CI 1.11-3.89, P=0.022). Conclusion: CDKN2B-AS1 SNP rs4977574 was related to female pCAD occurrence and it was also related to high HbA1c.
