Relationship between serum pentraxin 3 and rheumatic heart disease
10.3969/j.issn.1000-484X.2017.12.023
- VernacularTitle:血清正五聚蛋白3与风湿性心脏病的关系
- Author:
Xin SONG
1
;
Jun Ying CHE
;
Qiang Yong ZHANG
;
Lan Li LIU
;
Xue Zhi CHEN
Author Information
1. 泸州市合江县人民医院
- Keywords:
Rheumatic heart disease;
Pentraxin 3;
Hypersensitive c-reactive protein
- From:
Chinese Journal of Immunology
2017;33(12):1867-1869,1876
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the pentraxin 3 (PTX3),hypersensitive c-reactive protein (the hs-CRP) and rheumatic heart disease ( RHD) correlation and significance .Methods:40 healthy people with the same period in hospital as contral ,and selected 76 cases hospitalized patients with rheumatic ( excluding artificial after valve replacement in patients with rheumatic ) , according to the Color Doppler Echocardiography and electrocardiogram ( ECG ) were divided into the atrial fibrillation rhythm group ( 48 cases ) and sinus rhythm group ( 28 cases ) combined valve lesion group ( 46 cases ) and single valve lesion group ( 30 cases ) using immune enhanced turbidimetric method to determine the hs-CRP, enzyme-linked immunosorbent ( ELISA ) method to detect the contents of PTX3.Results:①RHD group serum hs CRP and PTX 3 level obviously was higher than the control group ( P<0.01 );②the level of serum PTX3 rheumatic atrial fibrillation group was obviously higher than that of sinus rheumatic group ( P<0.01 ) , but the hs-CRP serum level of rheumatic atrial fibrillation group and sinus rheumatic group had no statistical difference ( P>0.05 );③PTX3 level and hs-CRP levels in combined valve lesion group were higher than in single valve disease group (P<0.05).Conclusion:PTX3 and hs-CRP persist in rheumatic heart disease , rheumatic valvular disease of the seriousness of the hs-elevated CRP and PTX3 concentration.PTX3 is one of the influence factors of rheumatic atrial fibrillation occurred ,PTX3 higher stability in rheumatic heart disease inflammatory response performance .
