Application of Ischemia Modified Albumin for Acute Ischemic Heart Disease in Forensic Science
10.3969/j.issn.1004-5619.2017.05.009
- VernacularTitle:缺血修饰白蛋白在急性缺血性心脏病中的法医学应用
- Author:
Peng WANG
1
;
lei Ze ZHU
;
Ning ZHU
;
Hao YU
;
Qiang YUE
;
long Xiao WANG
;
mei Chun FENG
;
liang Chang WANG
;
hua Guo ZHANG
Author Information
1. 铁岭市公安局刑警支队
- Keywords:
forensic pathology;
death,sudden,cardiac;
myocardial ischemia;
albumins
- From:
Journal of Forensic Medicine
2017;33(5):493-496
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the application value and forensic significance of ischemia modified albumin (IMA) in pericardial fluid to diagnose sudden cardiac death.Methods IMA level in pericardial fluid was detected in acute ischemic heart disease group (n=36),acute myocardial infarction group (n=6),cardiomyopathy group (n=4) and control group (n=15) by albumin cobalt binding method.The levels of IMA were compared among these groups.The best cut-off IMA value was estimated and the sensitivity and specificity of acute myocardial ischemia group was distinguished from control group by receiver operating characteristics (ROC) curve.Results The IMA level in acute ischemic heart disease group was significantly higher than that of control group (P＜0.05).Compared with acute myocardial infarction group and cardiomyopathy group,the IMA level in acute ischemic heart disease group had no significant difference (P＜0.05).The cut-off value for the identification of acute myocardial ischemia which obtained by ROC analysis was 40.65U/mL.And the sensitivity and specificity for distinguishing acute ischemia cardiac disease was 60.0％ and 80.5％,respectively.Conclusion The IMA value in pericardial fluid can be a reference marker for the diagnosis of acute myocardial ischemia,which also can provide objective basis for the forensic identification of sudden cardiac death.
