Relationship Between Peripheral Blood Eosinophil Level and Acute Myocardial Infarction Combining Helicobacter Pylori Infection
10.3969/j.issn.1000-3614.2017.12.011
- VernacularTitle:外周血嗜酸性粒细胞水平与合并幽门螺杆菌感染的急性心肌梗死的关系
- Author:
lei Lei CHEN
1
;
zhao De WANG
Author Information
1. 首都医科大学附属北京天坛医院 心内科
- Keywords:
Myocardial infarction;
Helicobacter pylori;
Eosinophil;
C-reactive protein
- From:
Chinese Circulation Journal
2017;32(12):1185-1189
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the relationship betweenperipheral blood eosinophil(EOS) level and acute myocardial infarction(AMI) combining helicobacter pylori (Hp) infection, to compare EOS level in Hp(+) and Hp(-) AMI patients with the possible mechanism. Methods: A total of 662 patients with coronary heart disease(CHD) admitted in our hospital from 2015-09 to 2016-05 were retrospectively studied. The patients were divided into 2 groups: AMI group, n=269 and Stable angina pectoris(SAP) group, n=393; according to 13C breath test, the patients were divided into another set of 2 groups: Hp(+) group, Hp infection value≥4.0, n=276 and Hp(-) group, Hp infection value<4.0, n=386. Clinical data was collected, EOS levels were compared between Hp(+) and Hp(-) AMI patients; relationship between EOS level and high sensitivity C-reactive protein(hs-CRP) level was analyzed in Hp(+) AMI patients. Results: Compared with SAP group, AMI group had the higher rate of Hp(+) as 46.5%vs38.4%, P=0.024. In Hp(+) group, compared with SAP patients, AMI patients had the lower EOS level and higher hs-CRP level, all P<0.000. In Hp(+) AMI patients, EOS level was negatively related to hs-CRP(r=-0.202, P<0.05). Conclusion:Hp(+) AMI patients had decreased peripheral blood EOS and increased hs-CRP, it implied that Hp(+) may aggravate the inflammatory response in AMI patients and therefore, affect EOS which could play an important role in thrombus formation.
