Impact of Mean Platelet Volume on Prognosis in Patients With ST-segment Elevation Myocardial Infarction
10.3969/j.issn.1000-3614.2017.12.012
- VernacularTitle:平均血小板体积对急性ST段抬高型心肌梗死患者预后的影响
- Author:
Jia SONG
1
;
jun Zhi SUN
;
tong Tong YU
;
Lin ZHANG
;
xu Dong HE
;
yang Chun TIAN
;
qing Zhao SUN
Author Information
1. 中国医科大学附属盛京医院 心血管内科
- Keywords:
Myocardial infarction;
Mean platelet volume;
Angioplasty;
transluminal;
percutaneous coronary
- From:
Chinese Circulation Journal
2017;32(12):1190-1193
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the impact of mean platelet volume (MPV) on prognosis in patients with ST-segment elevation myocardial infarction (STEMI). Methods: A total of 1012 consecutive STEMI patients received percutaneous coronary intervention (PCI) in our hospital from 2010-01-01 to 2014-10-31 were enrolled. Major adverse cardiovascular events (MACE) were recorded in 2015-10. Based on ROC curve measured optimal critical point of MPV in all-cause death, the patients were divided into Low MPV group and High MPV group. The incidence of MACE was compared between 2 groups, the impact of MPV on prognosis of PCI treated STEMI patients was studied by uni- and multivariate COX regression analysis. Results: By ROC curve, the optimal critical point of MPV in all-cause death was MPV≤9. 466 fl. MPV≤9. 466 fl in Low MPV group, n=549 and MPV>9. 466 fl in High MPV group, n=463. The patients were followed-up for 34 (12-69) months. Compared with Low MPV group, the patients in High MPV group had the higher incidences of all-cause death and cardiac death, P<0. 001 and P=0. 001. With adjusted multivariates, COX regression analysis showed that MPV was an independent risk factor of all-cause death (HR=1. 463, P<0. 001) and cardiac death (HR=1. 458, P<0. 001) in relevant patients. Conclusions: Increased MPV at admission had the predictive value for long-term prognosis in PCI treated STEMI patients.
