Multicenter clinical research of splenic autotransplantation
10.3969/j.issn.1006-5725.2017.21.015
- VernacularTitle:脾外伤患者自体脾片移植的多中心临床研究
- Author:
Xinbin CHEN
1
;
De HE
;
Xingqun WANG
;
Rongjiang LI
;
Jun HAO
;
Yumin XU
;
Ke HU
;
Guangnian MA
Author Information
1. 深圳市宝安区人民医院普通外科
- Keywords:
traumatic splenic rupture;
splenectomy;
overwhelming post-splenectomy infection;
splenic autotransplantation;
immune function
- From:
The Journal of Practical Medicine
2017;33(21):3559-3562
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of splenic autotransplantation in patients with severe splenic trauma. Methods A prospective case-control study were performed in 120 patients with traumatic spleen rupture including the treatment group 72 patients and the control group 48 patients. The treatment group were treated with splenectomy plus spleen autotransplantation and the control group merely under splenectomy. Compare the operation time,operative blood loss,postoperative hospital stay,postoperative complications and the immune indexes before and different period after operation. Results Autologous spleen transplantation takes more time than merely splenectomy(P<0.05),but the operative blood loss,postoperative hospital stay and postopera-tive complications were no significant difference. 1 days after operation,the immune indexes of two groups were significantly lower than those before operation(P < 0.05),and 1 week after operation the immune indexes of two groups were significantly elevated(P<0.05).The immune indexes of the treatment group were better than those of the control group 3 months after operation(P < 0.05),and there was no significant difference compared with preoperative. Conclusion Splenectomy cause the decrease in the immune function,but the immune function can quickly rise to a certain level in short term.The splenic autotransplantation can effectively restore the immune func-tion to the preoperative level.
