Clinical study of carotid artery contrast-enhanced ultrasonography in evaluating the activity of Takayasu's disease
10.3760/cma.j.issn.1007-7480.2017.11.006
- VernacularTitle:颈动脉超声造影评价大动脉炎疾病活动性的临床研究
- Author:
Lingying MA
1
;
Chaolun LI
;
Xiufang KONG
;
Xiaojie ZHANG
;
Hong HAN
;
Zhenqi DING
;
Huiyong CHEN
;
Beijian HUANG
;
Lindi JIANG
Author Information
1. 复旦大学附属中山医院风湿免疫科
- Keywords:
Takayasu arteritis;
Contrast-enhanced ultrasonography;
Carotid arteries
- From:Chinese Journal of Rheumatology
2017;21(11):748-753
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the morphological changes of carotid artery wall by ultrasonography in patients with Takayasu arteritis,and to evaluate the diagnostic value of contrast-enhanced ultrasonography for active Takayasu arteritis.Methods High-frequency ultrasound technique was used to analyze the morphological changes of the carotid artery in 40 patients.NIH score was used as the gold standard and the complete clinical data and acute phase reactors were recorded.T test,Chi-square test,sensitivity and specificity were calculated for statistical analysis.Results The thickness of carotid artery wall in active group was much more thickened than the non-active group [(2.2±0.6) mm vs (1.8±0.5) mm,t=-2.142,P＜0.05].The CDD [(0.89±0.06) in active group vs (0.95±0.03) in non-active group,t=3.683,P＜0.01] and RDD [(0.17±0.06 in active group vs (0.09±0.05) in non-active group,t=-4.020,P＜0.01] were significantly different between the two groups.The distribution of neovascularization in the carotid artery wall of the active group was more diffuse in the central part of the wall.The sensitivity and specificity of contrast-enhanced ultrasonography to diagnose the active of Takayasu arteritis were 72.7％ and 87.5％ respectively,and the positive predictive value and the negative predictive value were 80.0％ and 82.4％ respectively.Conclusion Contrast-enhanced ultrasonography can be used as an effective way to assess the disease activity of TA patients.
