Effects of light acute hypervolemic hemodilution on early postoperative cognitive function in elderly patients
10.3969/j.issn.1006-5725.2017.21.023
- VernacularTitle:轻度急性高容量血液稀释对老年患者术后早期认知功能的影响
- Author:
Hanwen CHEN
1
;
Zumin XING
;
Xiaolei LIU
;
Yanjing ZHANG
;
Jiyuan LI
;
Zhiqiang CHEN
;
yun Cui ZHOU
;
Yiwen ZHANG
Author Information
1. 南方医科大学顺德医院麻醉科
- Keywords:
acute hypervolemic hemodilution;
elderly;
cognitive function
- From:
The Journal of Practical Medicine
2017;33(21):3589-3592
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of light acute hypervolemic hemodilution on early postop-erative cognitive function in elderly patients. Methods A total of 60 patients treated by radical surgery were equally randomized to an AHH and a non-AHH control group.Using the Mini-Mental State Examination scale (MMSE),we evaluated the cognitive function of the patients.We made comparisons between the two groups in the plasma S100β levels at T0(before anesthesia induction),T1(immediately after hemodilution),T2(immediately after operating),T(36 hour after operating)and T(424 hour after operating).Results The S-100β lever at T2、T3 and T4were markedly higher than T0in both groups(P<0.05);At T3and T4,the S-100β lever was higher in non-AHH control group than AHH group(P<0.05).There was no significant difference in the incidence of postopera-tive cognitive dysfunction between the two groups(P>0.05)There was no significant difference in the incidence of postoperative cognitive dysfunction between the two groups(P > 0.05). Conclusions AHH can significantly reduce plasma S100β in elderly patients,but there is no effect on early postoperative cognitive function.
