Study on the Distribution Law of Valsartan Capsules in the Ocular Tissue of Rabbit Eyes after Intragastri-cal Administration
10.6039/j.issn.1001-0408.2017.34.14
- VernacularTitle:缬沙坦胶囊灌胃给药后在兔眼组织的分布规律研究
- Author:
Zhijin LI
1
;
Jing LI
;
Yue ZHANG
;
Zanzhang YANG
Author Information
1. 河北省眼科医院药剂科/河北省眼科学重点实验室
- Keywords:
Valsartan;
HPLC;
Ocular tissue;
Rabbit;
Distribution
- From:
China Pharmacy
2017;28(34):4808-4811
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the distribution law of Valsartan capsules in the ocular tissue of rabbit eyes after intragastri-cal administration. METHODS:3 rabbits(6 eyes)were intragastrically administrated Valsartan solution,7.5 mg every time,twice a day,for 6 d. Rabbits were executed after last administration,and the cornea,iris,aqueous humor,lens,vitreous and retina tis-sues were collected. HPLC was used to determine the content of valsartan in each tissue. RESULTS:Content of valsartan in retina, iris,cornea,aqueous humor,vitreous and lens were (4.274 ± 1.75),(2.233 ± 0.72),(0.871 ± 0.66),(0.713 ± 0.49),(0.177 ± 0.07),(0.083 ± 0.06)μg/g,respectively. CONCLUSIONS:After multiple administrations,valsartan distributes unevenly in each tissue of eyes,showing highest distribution content in retina,followed by iris,and lowest content in lens and vitreous.
