Effect of Shenkang Injection on the Irbesartan Pharmacokinetics in Rats in vivo
10.6039/j.issn.1001-0408.2017.34.16
- VernacularTitle:肾康注射液对大鼠体内厄贝沙坦药动学的影响
- Author:
Zhenji JIN
1
;
Zena CHANG
;
Zhenhan ZHU
;
Changqing YANG
Author Information
1. 延边大学附属医院药学部
- Keywords:
Shenkang injection;
Irbesartan;
Pharmacokinetics;
Rats
- From:
China Pharmacy
2017;28(34):4815-4817
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effect of Shenkang injection on the irbesartan pharmacokinetics in rats in vivo. METH-ODS:18 SD rats were randomly divided into control group(normal saline)and Shenkang injection(calculated by crude drug as 4 g/kg),9 in each group,which were intraperitoneally injected twice a day,for 7 d. After 1 h of last administration,25 mg/kg irbe-sartan was intragastrically administrated. 0.3 mL sample blood was taken in fundus venous plexus before administration of irbesartan and after 0.25,0.5,1,2,4,8,12,24,32,48,56,72,96 h of administration. Using biphenyl diester as inner standard,HPLC was adopted to determine the plasma concentration of irbesartan in plasma of rats,and pharmacokinetic parameters were calculated by using non-compartmental model in Phoenix WinNolin? 6.1 pharmacokinetic software. RESULTS:After intragastrically adminis-trated irbesartan in rats in control group and Shenkang injection group,AUC0-96 h were (28.82 ± 10.49),(35.64 ± 9.99) mg·h/L;cmax were(0.64±0.15),(0.76±0.33)mg/L;tmax were(13.07±16.70),(10.23±3.97)h;CLZ/F were(0.85±0.35),(0.63±0.21) L/(h·kg);VZ/F were (38.24 ± 24.87),(30.99 ± 9.75) mL/kg respectively,with no statistical significances (P>0.05). CONCLU-SIONS:Shenkang injection will not affect the in vivo pharmacokinetics process of irbesartan in normal dose on rats.
