Drug Induced Parkinsonism Caused by the Concurrent Use of Donepezil and Risperidone in a Patient With Traumatic Brain Injuries.
10.5535/arm.2013.37.1.147
- Author:
Si Hyun KANG
1
;
Don Kyu KIM
Author Information
1. Department of Physical Medicine & Rehabilitation, Chung-Ang University College of Medicine, Seoul, Korea. donkim21@gmail.com
- Publication Type:Case Report
- Keywords:
Parkinsonian disorders;
Donepezil;
Risperidone;
Brain injuries
- MeSH:
Anxiety;
Arm;
Brain Injuries;
Delusions;
Dopamine Plasma Membrane Transport Proteins;
Electrons;
Humans;
Hypokinesia;
Indans;
Male;
Mild Cognitive Impairment;
Neuropsychiatry;
Parkinson Disease;
Parkinsonian Disorders;
Piperidines;
Posture;
Risperidone;
Tremor;
Walking
- From:Annals of Rehabilitation Medicine
2013;37(1):147-150
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 69-year-old male patient with previous history of traumatic brain injury 5 months ago was admitted to the Department of Neuropsychiatry because of aggressive behavior and delusional features. After starting on 2 mg of risperidone per day, his delusion, anxiety, and aggressive behavior gradually improved. Two weeks later, he was given 10 mg of donepezil per day for his mild cognitive impairment. After 6 weeks of admission in the Department of Neuropsychiatry, he showed parkinsonian features including difficulty in walking, decreased arm swing during walking, narrowed step width, scooped posture, bradykinesia, tremor, and sleep disorder. To rule out the primary Parkinsonism, dopamine transporter imaging technique [18F]fluoropropyl-carbomethoxy-iodopropyl-nor-beta-tropane positron emission tomography-computed tomography (18F]FP(IT PET-CT)) was performed, and dopamine transporter activity was not decreased. We considered that his parkinsonian features were associated with the combination of risperidone and donepezil. Both drugs were stopped and symptoms rapidly disappeared in several days.
