Role of Wnt/beta-catenin signaling pathway during tooth root development
- VernacularTitle:Wnt/β-catenin信号通路对牙根发育的影响
- Author:
Mei HE
1
;
yuan Jia WU
Author Information
1. 遵义医学院
- From:
Chinese Journal of Tissue Engineering Research
2017;21(28):4556-4562
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Wnt/β-catenin signaling pathway plays an important role in tooth development and especially in the root development,including the initiation of root development,Hertwig's epithelial root sheath formation,root odontoblast and cementoblast proliferation and differentiation process.OBJECTIVE:To explain the effect of Wnt/β-catenin signaling pathway on tooth root development.METHODS:CNKI and PubMed databases were searched for the literatures concerning odontoblast and cementoblast proliferation and differentiation as well as Hertwig's epithelial root sheath formation mediated by Wnt/β-catenin signaling pathway during root development.Finally 41 eligible articles were enrolled according to the inclusion and exclusion criteria.RESULTS AND CONCLUSION:During the tooth root development,Wnt/β-catenin signaling pathway can regulate Hertwig's epithelial root sheath integrity,so the inhibition of signaling pathway will block Hertwig's epithelial root sheath formation,further inducing the failure in root odontoblasts and cementoblast differentiation.Loss or overexpression of the signal transduction pathway will inhibit the proliferation and differentiation of odontoblasts,and appear with root dentin formation disorder.Effect of β-catenin signal on cementum differentiation can be regulated by cell origin or developmental stage,surrounding microenvironment and Wnt-related activator and inhibitor concentration,thereby promoting or inhibiting cementoblasts to different exents.
