Progress of Metal Nanoclusters-based Electrochemiluminescent Analysis
10.11895/j.issn.0253-3820.171292
- VernacularTitle:基于金属纳米簇的电化学发光分析应用研究进展
- Author:
Hui JIANG
1
;
Mei Xue WANG
Author Information
1. 东南大学生物科学与医学工程学院
- Keywords:
Metal nanoclusters;
Electrochemiluminescence;
Signal amplification;
Bioanalysis;
Review
- From:
Chinese Journal of Analytical Chemistry
2017;45(12):1776-1785
- CountryChina
- Language:Chinese
-
Abstract:
In the past ten years, the development of electrochemiluminescent ( ECL ) analytical methods based on various types of nanostructures has become a research hotspot. Nanocluster, an intermediate between molecules and conventional nanoparticles, is renowned for its luminescent feature. The first report on ECL for nanoclusters can be traced back to 2009 . Here we summarized the main research progresses since 2011 . Firstly, the preparation of ECL-related nanoclusters was briefly introduced. Then, the mechanisms and applications of ECL by nanoclusters were described. To improve ECL performances, two main strategies, i. e. , nanostructure-based ECL enhancement and biological signal amplification were proposed. Besides, the nanoclusters as the energy transfer receptors in ECL systems were also discussed. In prospect part, the future development of ECL by nanoclusters was considered. We believed that the synthesis of high quality nanoclusters, the reveal of ECL structure-activity relationships, the rationale design and application of near-infrared ECL, and the role of ECL in the interdisciplinary research were the main problems we faced in the future.
