Development of Multiplex Immunoassay Based on Inductively Coupled Plasma Mass Spectrometry
10.11895/j.issn.0253-3820.171324
- VernacularTitle:电感耦合等离子体质谱用于多组分免疫分析研究进展
- Author:
Wei Gong SUN
1
;
Zhe Wei HONG
;
Qing Yu ZHANG
;
An Zhi HU
;
Zhi XING
;
Chun Si ZHANG
;
Rong Xin ZHANG
Author Information
1. 清华大学化学系,北京100084
- Keywords:
Immunoassay;
Inductively coupled plasma mass spectrometry;
Multiplex immunoassay;
Review
- From:
Chinese Journal of Analytical Chemistry
2017;45(12):1786-1794
- CountryChina
- Language:Chinese
-
Abstract:
Immunoassay is of great importance in the field of clinical detection. Our group proposes the inductively coupled plasma mass spectrometry ( ICP-MS) based immunoassay. Multiplex immunoassay can be realized by stable isotope tagging strategy combined with ICP-MS detection. Since then, large amount of researches in this field have been made at home and abroad, and the method has been proved applicable to the analysis of biological small molecules, proteins, nucleic acids and cells. In this article, the history and development of immunoassay, the characters of ICP-MS based immunoassay, single component and multiplex immunoassay, and the magnetic immunoassay that is recently fast developed are reviewed. The prospect of the developing tendency is also anticipated, hoping to provide references for the research in this field.
