Clinical Research on Detecting the Serum Amyloid A Level of Pregnant Woman in Early Primary Unexplained Recurrent Spontaneous Abortion
10.3969/j.issn.1671-7414.2017.06.012
- VernacularTitle:孕妇血清淀粉样蛋白A水平检测与早期原发性不明原因复发性流产的临床相关性研究
- Author:
Ying CAO
1
;
hua Chun LIU
;
li Ya YANG
Author Information
1. 宝鸡市妇幼保健院产科
- Keywords:
primary unexplained REPL;
SAA;
syncytialization;
trophoblastic invasion
- From:
Journal of Modern Laboratory Medicine
2017;32(6):43-45,49
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the serum amyloid A(SAA)levels of primary unexplained recurrent early pregnancy loss (REPL),and discuss the viability of regarding the SAA as a independent indicator of REPL.Methods A prospective study was conducted among 96 women with missed spontaneous abortion at Baoji Maternal and Child Care Hospital from January to December 2014.A control group was formed of pregnant women with no history of REPL.Serum samples of both groups were collected to measure SAA levels by enzyme linked immunosorbent assay.The association between SAA and primary unexplained REPL were analyzed according to the multiple factors Logistic models,and the diagnostic value of SAA to RE-PL were detected through receiver operating characteristic.Results Median SAA level was significantly higher among women with REPL(50 μg/ml,interquartile range 26.0~69.0 μg/ml),than that in the control group(11.6 μg/ml,inter-quartile range 6.2~15.5 μg/ml,P=0.000<0.01).The diagnose value of SAA to REPL was perfect good(AUC=0.91), and the most accurate value was 18 μg/ml.The SAA level was an independent indicator of primary unexplained REPL,after adjusting for maternal age and gestational age(OR:1.12,P=0.000).Conclusion Elevated SAA levels found among women with primary unexplained REPL could represent a novel biomarker for this complication of pregnancy.
