Analysis of the Correlation between Mutations of the Epidermal Growth Factor Receptor Gene and Pathological of Non Small Cell Lung Cancer
10.3969/j.issn.1671-7414.2017.06.022
- VernacularTitle:表皮生长因子受体基因突变与非小细胞肺癌病理的相关性分析
- Author:
qing Yong ZHANG
1
;
qun Li SHANG
;
Yi MIAO
;
lin Rui CHEN
;
mei Shu YANG
;
Jie DU
Author Information
1. 陕西省人民医院
- Keywords:
epidermal growth factor receptor;
non small cell lung cancer;
gene mutation;
targeted therapy
- From:
Journal of Modern Laboratory Medicine
2017;32(6):78-80
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between pathological of non small cell lung cancer(NSCLC)and mutations of the epidermal growth factor receptor(EGFR)gene.Methods Selected 96 patients with lung cancer for EGFR mutation de-tection in Shaanxi Provincial People's Hospital from January 2014 and April 2015,comparison of different types of NSCLC EGFR mutation rate.Results Gene mutation sensitive in 24 cases,in 12 cases and location of the mutation L858R,10 cases of mutation at position 19DEL,1 cases of mutation position G719X and S768I,1 cases EML4-ALK fusion.Mutation rate of 29.17%.Slightly lower than the international and domestic NSCLC epidermal growth factor receptor gene mutation sensitive rate of 30% of the average.Conclusion Target to treatment is aimed at the effective means for the treatment of NSCLC pa-tients with individualized,has reliable efficacy,less toxicity and adverse reactions,will become one of the most promising treatment,the study results below average,less attention to the base of the study population and need to raise awareness of routine testing.
