Level and Correlationship of Serum SOD and hsCRP and Other Indicators in Acute Coronary Syndrome
10.3969/j.issn.1671-7414.2017.06.033
- VernacularTitle:血清SOD和hsCRP等指标在急性冠脉综合征中的应用及相关性分析
- Author:
ling Yong LIU
1
;
long Hou LUO
;
chao Xing LIU
;
Jing ZHAO
;
xiang Zi PAN
;
Yan NONG
Author Information
1. 中国人民解放军第一八一医院
- Keywords:
acute coronary yndrome(ACS);
superoxide dismutase(SOD);
high-sensitive C-reactive protein(hsCRP)
- From:
Journal of Modern Laboratory Medicine
2017;32(6):115-117,121
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the level of serum superoxide dismutase(SOD),high-sensitive C-reactive protein (hsCRP)and myocardial injury markers in acute coronary syndrome(ACS)and evaluate their relationship and diagnostic values.Methods Case control study was conducted.This study enrolled 64 ACS patients and 50 non-ACS patients from the 181st Hospital of Chinese PLA in 2015.Serum SOD,hsCRP were tested and myocardial injury markers such as cardiac tro-ponin I(cTnI),creatin kinase MB(CK-MB)were also tested.Student t test and Pearson test were used as statistical meth-ods.Results Compared with control group,SOD of ACS group were significant lower(t=4.136,P<0.001)and hsCRP, Mb,cTnI,CK and CK-MB were significant higher(t=-5.396,-3.495,-5.578,-4.655 and -4.614,all P<0.001). The area under ROC curve of SOD,hsCRP,MYO,cTnI,CK and CK-MB was 0.713,0.758,0.699,0.879,0.841 and 0.802 respectively.After pearman test,the serum SOD were correlated to hsCRP,total cholesterol(TC)and low density lipopro-tein(LDL-C)(r=-0.493,0.548 and 0.404,all P<0.01).Serum hsCRP was correlated to cTnI,triglyceride(TG)and SOD(r=0.671,-0.417 and -0.493,all P<0.01).Conclusion cTnI was positively correlated to hsCRP and markers of myocardial injury.hsCRP was negatively correlated with SOD.It implicated that oxidative stress,inflammatory response and serum lipid deposition may act an important role in the occurrence and development of ACS.
