Clinical value of serum (1-3 )-β-d-glucan detection on diagnosis of deep fungal infection
10.3969/j.issn.1673-4130.2017.22.013
- VernacularTitle:血清(1-3)-β-D葡聚糖检测在深部真菌感染诊断中的临床价值
- Author:
Ying CHENG
1
;
Beinan ZENG
;
Yan LIU
;
Ran CHENG
;
Shuang LIU
;
Ke LI
Author Information
1. 重庆市血液中心社会事务部
- Keywords:
IFD;
(1-3)-β-D-glucan;
fungal culture
- From:
International Journal of Laboratory Medicine
2017;38(22):3107-3108,3112
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of serum (1-3)-β-D-glucan(BG) detection (G test) in early diagnosis of deep fungal infection .Methods 132 patients with suspected deep fungal infection in the Chongqing Emergency Medical Center from October 2015 to April 2016 were selected as the research subjects .Among them ,38 cases definitely diagnosed and suspected diagnosed deep fungal infection served as the positive group and other 94 cases were taken as the negative group .Serum BG level was measured by Jinshanchuan MB-80 microbial dynamic detection system ,and the results were compared with the fungal culture results by the body fluid fungal culture .Results The serum BG level of the positive group was (150 .8 ± 133 .2)pg/mL ,and which of the negative group was (25 .7 ± 20 .1)pg/mL ,the difference was statistically significant (t=5 .76 ,P＜0 ,05) .The sensitivity ,specificity ,positive predictive value and negative predictive value of G test were 78 .9% ,85 .1% ,68 .1% and 91 .0% respectively ;the sensitivity ,specificity ,positive predictive value and negative predictive value of fungal culture were 57 .9% ,80 .9% ,52 .3% and 82 .6%respectively .Conclusion The serum BG detection is fast ,accurate ,simple and convenient ,and has clinical application value in the early diagnosis of deep fungal infection and clinical rational medication guidance .
