Clinical value of PEDF ,A beta ,Hcy and β-EP in the diagnosis of primary glaucoma
10.3969/j.issn.1673-4130.2017.22.019
- VernacularTitle:PEDF、Aβ、Hcy和β-EP在原发性青光眼诊断中的临床价值
- Author:
Juan CHENG
1
;
Xiao LIU
Author Information
1. 武汉市爱尔眼科医院汉口医院眼科
- Keywords:
primary glaucoma;
Aβ;
Hcy;
β-EP;
clinical value
- From:
International Journal of Laboratory Medicine
2017;38(22):3125-3127
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change of serum pigment epithelium derived factor (PEDF) ,β amyloid (Aβ) ,homocysteine (Hcy) and β endorphin (β-EP) levels in the patients with primary glaucoma and their clinical value .Methods 93 cases of primary glaucoma and 93 healthy people from July 2011 to June 2015 were selected as the primary glaucoma group and control group respectively .The ultrasound biomicroscopic examination results served as the golden standard .The changes of PEDF ,Aβ,Hcy and β-EP levels were observed in the two groups .Their sensitivity ,specificity and accuracy were compared .Results The PEDF level in the primary glaucoma group was significantly lower than that in the control group ,while serum Aβ,Hcy and β-EP levels were significantly higher than those in the control group ,the differences were statistically significant (P＜0 .05) .In the Richardson stage of primary glaucoma severity ,the higher the grade ,the higher the serum Aβ,Hcy and β-EP levels ,while the lower the PEDF level ,the differences were statistically significant (P＜0 .05) .The sensitivity ,specificity and accuracy of serum PEDF ,Aβ,Hcy and β-EP combined detection were 97 .26% ,90 .00% and 95 .70% respectively ,which were significantly higher than that of single index detection or other indexes combined detection(P＜0 .05) .Conclusion The levels of serum PEDF ,Aβ,Hcy and β-EP are higher in the patients with primary glaucoma and their combined detection has a great value for evaluating the severity of primary glaucoma .
