Food-dependent exercise-induced anaphylaxis in Korea: a multicenter retrospective case study.
10.4168/aard.2013.1.3.203
- Author:
Jae Hyoung IM
1
;
Hea Yoon KWON
;
Young Min YE
;
Hae Sim PARK
;
Tae Bum KIM
;
Gil Soon CHOI
;
Joo Hee KIM
;
Gwang Cheon JANG
;
Mi Kyung KIM
;
Gyu Young HUR
;
Young Il KOH
;
Seong Wook SOHN
;
Cheol Woo KIM
Author Information
1. Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea. cwkim1805@inha.ac.kr
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Food hypersensitivity;
Exercise;
Anaphylaxis
- MeSH:
Aged;
Anaphylaxis;
Epinephrine;
Follow-Up Studies;
Food Hypersensitivity;
Humans;
Immunoglobulin E;
Immunoglobulins;
Korea;
Meat;
Retrospective Studies;
Seafood;
Triticum;
Vegetables
- From:Allergy, Asthma & Respiratory Disease
2013;1(3):203-210
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To investigate the causes, clinical features and characteristics of food-dependent exercise-induced anaphylaxis (FDEIA) in Korea. METHODS: A retrospective medical chart review was performed on the patients diagnosed with anaphylaxis between 2007 and 2011 in 14 hospitals in Korea. Cases with FDEIA were subsequently identified among anaphylaxis patients, and subgroup analyses were done to assess clinical characteristics of FDEIA. RESULTS: A total of 62 subjects with FDEIA (male, 72.6%; aged 16 to 70 years) were enrolled in 10 hospitals. Wheat (69.3%) was the most common cause of FDEIA, followed by meat (8.1%), seafood (6.5%), and vegetables (6.5%). The clinical manifestations were cutaneous (100%), respiratory (64.5%), cardiovascular (61.3%), and gastrointestinal (9.7%), respectively. In severity assessment, approximately 40% of FDEIA were classified as severe anaphylaxis. Portable epinephrine auto-injector was prescribed to 17.2% of patients, and about one fifth of the patients experienced redevelopment of anaphylactic symptoms during follow-up period. There was no significant difference of age, gender, latent period, total immunoglobulin E, and past history of allergic disease between patients with severe anaphylaxis group and patients with mild-to-moderate group. CONCLUSION: Wheat is the most common cause of FDEIA in Korea. Because significant number of patients with FDEIA experienced anaphylactic symptoms after diagnosis of FDEIA, more comprehensive therapeutic and educational approaches will be required to prevent recurrent development of anaphylaxis.
