Association between Nrf2 Gene-653G/A,-651G/A and-617C/A Polymorphism and Susceptibility of Parkinson's Disease
10.3969/j.issn.1671-7414.2017.06.017
- VernacularTitle:Nrf2基因启动子-653G/A,-651G/A和-617C/A位点单核苷酸多态性与帕金森病易感性的关联性研究
- Author:
Qi WU
1
;
hua Bao ZHANG
Author Information
1. 安康市中医医院
- Keywords:
parkinson's disease;
NF-E2-related factor 2;
gene polymorphism
- From:
Journal of Modern Laboratory Medicine
2017;32(6):60-63
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the genetic association between NF-E2-related factor 2(Nrf2)gene polymorphism and susceptibility to Parkinson's disease(PD)in the Han descent population of Shaanxi Province.Methods 553 PD patients from January 2015 to December 2016 were recruited to participate in the study as the PD group.According to the age of on-set,they were divided into early-onset Parkinson's disease(EOPD)group(186 cases),and late-onset Parkinson's disease (LOPD)group(367 cases).350 healthy volunteers without PD were randomly selected in their hospital in the same period of time as the control group.Genotype was determined by polymerase chain reaction combined with DNA direct sequencing technique for the polymorphism of the Nrf2 gene.Results The genotype and allele distribution of Nrf2-653G/A polymor-phism were significantly different between the EOPD group and control group(χ2=6.032,5.652,all P<0.05).There was no significant difference of genotype and allele distribution of three Nrf2 gene single nucleotide polymorphisms(SNPs)be-tween the PD group and control group,or LOPD group and control group,or EOPD group and LOPD group(all P>0.05). The frequency of haplotype A-A-C[(-653G/A)-(-651G/A)-(-617C/A)]were significantly different between the EOPD group and control group,and EOPD group and LOPD group(χ2=6.566,8.350,P=0.011,0.004).However,there was no significant difference of Nrf2 haplotype between the PD group and control group,or LOPD group and control group(all P>0.05).Conclusion Polymorphism of the Nrf2(-653G/A)gene maybe associated with the risk of PD.
