Vitamin D insufficiency is associated with food sensitization in children under 2 years with atopic dermatitis.
10.4168/aard.2013.1.3.211
- Author:
Jong Uk BAEK
1
;
Jun Won HWANGBO
;
Hae Ran LEE
;
So Yeon LEE
Author Information
1. Department of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea. imipenem@hanmail.net
- Publication Type:Original Article
- Keywords:
Vitamin D;
Food;
Sensitization;
Dermatitis;
Atopic
- MeSH:
Allergens;
Child;
Dermatitis;
Dermatitis, Atopic;
Eosinophils;
Heart;
Humans;
Immunoglobulin E;
Immunoglobulins;
Logistic Models;
Medical Records;
Odds Ratio;
Vitamin D;
Vitamins
- From:Allergy, Asthma & Respiratory Disease
2013;1(3):211-215
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Vitamin D levels are known to be associated with development of allergic diseases. However, existing data are controversial. The aim of this study was to investigate whether vitamin D levels are associated with food sensitization (FS) in young children with atopic dermatitis (AD). METHODS: We performed a medical record review of all patients under 2 years presenting to pediatric allergic clinic in Hallym University Sacred Heart Hospital for atopic dermatitis between March 1, 2012 and February 28, 2013. Serum 25-hydroxyvitamin D (25(OH)D)levels and six specific immunoglobulin E (IgE) to common food allergens were measured in 132 young children with AD. We defined vitamin D insufficiency was 25(OH)D <30 ng/mL, and FS as specific IgE > or =0.35 IU/mL to any of six common food allergens. Associations between serum 25(OH)D levels and FS were examined by using multiple logistic regression, adjusting for potential risk and confounding factors. RESULTS: The mean age was 10.1 months. Among the 132 children with AD, 65.9% had FS. In this group, there was a negative correlation between 25(OH)D levels and serum eosinophil percentage (correlation coefficient [r]=-0.335, P<0.01), but not correlated with serum total IgE levels. Children with vitamin D insufficiency were more likely to have FS (adjusted odds ratio, 17.1; 95% confidence interval, 1.36 to 215; P=0.028) than those with adequate vitamin D levels. CONCLUSION: Vitamin D insufficiency is associated with FS in young children with AD. Further research is needed to confirm these findings.
