Application of Serum DBIL,TBIL,DBIL/TBI Detection in the Diagnosis of Drug-induced Liver Injury
10.3969/j.issn.1671-7414.2017.06.044
- VernacularTitle:血清DBIL,TBIL,DBIL/TBIL检测在药物性肝损伤诊断中的应用
- Author:
Bo LIU
1
;
qin Hui ZHANG
;
li Rong ZOU
Author Information
1. 陕西省人民医院
- Keywords:
drug-induced liver disease;
clinical feature;
prognostic factor
- From:
Journal of Modern Laboratory Medicine
2017;32(6):151-153,159
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the functions of total bilirubin(TBIL)and direct bilirubin(DBIL),DBIL/TBIL detection in the diagnosis of drug-induced liver injury(DILI).Methods The clinical data and laboratory examination results of the pa-tients with drug-induced liver disease in Shaanxi Provincial People's Hospital were collected from January 2014 to December 2016.The factors were assessed by uni-variate and multivariate logistic regression analysis.Results In all,162 cases identi-fied as DILI were included in the study.The main causative group of drugs was Chinese herb(about 88 cases,54.3%).A-mong these 162 cases,124 cases(76.5%)were hepatocellular damage type,30 cases(18.5%)cholestatic damage type and 8 cases(4.9%)mixed type damage.It showed that the complete recovery occurred in 120 patients(74.1%)and the non-re-covery occurred in 41(25.3%),of which one death(0.6%).The binary logistic regression analysis identified the jaundice, DBIL,TBIL and DBIL/TBIL as independent factors of the non-recovery of DILI.Conclusion The main causative group of drugs was Chinese herb and the hepatocellular damage type was the commonest one.What's more,whether the case pro-gress into non-recovery one,was related to jaundice,TBIL,DBIL and DBIL/TBIL.
