Analysis of Reference Intervals of 18 Routine Biochemistry in 56 Mutual Recognition Laboratories in Beijing-Tianjing-Hebei Region
10.3969/j.issn.1671-7414.2017.06.045
- VernacularTitle:京津冀地区56家临床检验结果互认实验室18个常规化学项目参考区间结果分析
- Author:
ting Ting LI
1
;
jian Hai ZHAO
;
Wei WANG
;
lin Fa HE
;
Kun ZHONG
;
Shuai YUAN
;
guo Zhi WANG
Author Information
1. 北京医院 国家老年医学中心 卫生部临床检验中心/北京市临床检验工程技术研究中心
- Keywords:
reference interval;
examination;
quality control;
biochemistry;
clinical laboratory
- From:
Journal of Modern Laboratory Medicine
2017;32(6):154-159
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate reference intervals consistency of 18 routine biochemistry among mutual recognition labora-tories by analyzing the information of reference intervals of these laboratories in Beijing-Tianjing-Hebei region.Methods Laboratories submitted the data of reference intervals via interval quality assessment(EQA)software which was based on WEB,then the background of the software save the data as Microsoft Excel 2007 document.Finally,the mutual recognition routine biochemical projects,including Kalium(K),Sodium(Na),Chlorinum(Cl),Calcium(Ca),Phosphorus(P),Total protein(TP),Albumin(ALB),Total cholesterol(TC),Triglyceride(TG),Creatinine(CRE),Urea(URE),Uric acid (UA),Glucose(GLU),Alanine amino transaminase(ALT),Aspartate aminotransferase(AST),γ-glutamyltranspeptidase (GGT),Lactate dehydrogenase(LDH)and Creatine kinase(CK)of 56 mutual recognition laboratories were chosen,and perform analysis on upper and lower limits of reference intervals and their sources.Results The sources of reference inter-vals differ among different laboratories.As for projects owning hygiene professional standards(including K,Na,Cl,Ca,P, TP,ALB,CRE,URE,ALT,AST,GGT,LDH,CK),the primary sources were hygiene professional standards(23.1%~48.1%),manufacturer instructions of reagents/instrument(17.3%~41.8%)and National Clinical Laboratory Procedures (18.9% ~37.0%),as for projects which didn't have professional standards(including TC,TG,UA and GLU),the main sources were manufacturer instructions of reagents/instrument(>41.1%)and National Clinical Laboratory Procedures(>45.3%).Moreover,more than half of laboratories(50.9%~58.9%)had verified the reference intervals.There were little difference among laboratories in the upper and lower limits of Cl,Ca,P,K and GLU,but bigger difference for other projects. Conclusion The upper and lower limits of reference intervals werenot consistent among laboratories.In order to ensure the comparability of the test results in beijing-tianjin-hebei region,laboratories should use reference intervals based on the popu-lation of beijing-tianjin-hebei region or China.
